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Related Concept Videos

¹³C NMR: ¹H–¹³C Decoupling01:04

¹³C NMR: ¹H–¹³C Decoupling

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The probability of having two carbon-13 atoms next to each other is negligible because of the low natural abundance of carbon-13. Consequently, peak splitting due to carbon-carbon spin-spin coupling is not observed in spectra. However, protons up to three sigma bonds away split the carbon signal according to the n+1 rule, resulting in complicated spectra.
A broadband decoupling technique is used to simplify these complex, sometimes overlapping, signals. Broadband decoupling relies on a...
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Related Experiment Video

Updated: Sep 13, 2025

Technical Aspect of the Automated Synthesis and Real-Time Kinetic Evaluation of [11C]SNAP-7941
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Fully Automated Radiosynthesis of No-Carrier-Added [11C]Butanol Using the GE FASTLab 2 Module.

Ivan E Wang1, Jason A Witek2, Ryan J Pakula2

  • 1Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.

Journal of Labelled Compounds & Radiopharmaceuticals
|August 1, 2025
PubMed
Summary
This summary is machine-generated.

A new method for synthesizing [11C]butanol, a tracer for measuring brain blood flow, was developed using the GE FASTLab 2. This cassette-based radiosynthesis is fast, reliable, and comparable to older methods.

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Area of Science:

  • Radiochemistry
  • Nuclear Medicine
  • Neuroscience

Background:

  • Radiolabeled alcohols are used to measure cerebral blood flow.
  • [11C]butanol is a suitable tracer due to its diffusion, retention, and solubility properties.
  • It aids in assessing blood supply and substrate utilization.

Purpose of the Study:

  • To describe a no-carrier-added [11C]butanol radiosynthesis using the GE FASTLab 2.
  • To evaluate the benefits of a cassette-based workflow.
  • To compare this new method with legacy radiosynthesis on GE TracerLab FX modules.

Main Methods:

  • No-carrier-added [11C]butanol radiosynthesis was performed on the GE FASTLab 2.
  • The radiosynthesis utilized a cassette-based workflow.
  • Results were compared to a legacy synthesis on GE TracerLab FX modules.

Main Results:

  • The GE FASTLab 2 enabled [11C]butanol synthesis in 21 minutes.
  • Radiochemical yields ranged from 4% to 8% (n=3).
  • Radiochemical purity exceeded 90%, with synthesis being fast and reliable.

Conclusions:

  • The GE FASTLab 2 provides a fast and reliable method for [11C]butanol radiosynthesis.
  • This cassette-based workflow is comparable to legacy GE TracerLab FX modules.
  • [11C]butanol remains a valuable radiotracer for cerebral blood flow studies.