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Updated: Sep 13, 2025

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PCP4 inhibits the progression of prostate cancer through Ca2+/CAMKK2/AMPK/AR pathway

Wenqiao Jia1,2, Zeyuan Yu2, Feifei Sun3

  • 1Department of Health Management Center, Qilu Hospital of Shandong University, Jinan, China.

Frontiers in Immunology
|August 1, 2025
PubMed
Abstract

Insights

Purkinje cell protein 4 (PCP4) loss is frequent in prostate cancer (PCa), especially castration-resistant PCa (CRPC). PCP4 suppresses PCa progression by regulating the Ca2+/CAMKK2/AMPK/AR signaling pathway.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Signaling Pathways

Background:

  • Prostate cancer (PCa) is a significant global health concern.
  • Purkinje cell protein 4 (PCP4) downregulation is observed in PCa, particularly castration-resistant PCa (CRPC).
  • The Calcium/Calmodulin signaling pathway is implicated in various cancers.

Purpose of the Study:

  • To investigate the role of PCP4 in prostate cancer progression.
  • To elucidate the molecular mechanism of PCP4's tumor suppressive function.
  • To analyze the relationship between PCP4 expression and PCa clinicopathological characteristics.

Main Methods:

  • Analysis of public datasets for PCP4 expression and correlation with PCa characteristics.
  • In vitro and in vivo gain- and loss-of-function studies in PCa models.
  • Molecular and biochemical experiments to determine PCP4's mechanism of action.

Main Results:

  • PCP4 gene loss is frequent in PCa, correlating with poor prognosis and CRPC development.
  • PCP4 suppresses PCa progression in vitro and in vivo.
  • PCP4 regulates the Ca2+/CAMKK2/AMPK/AR signaling axis, acting as an androgen receptor-suppressed gene.

Conclusions:

  • PCP4 downregulation promotes PCa progression through the Ca2+/CAMKK2/AMPK/AR pathway.
  • PCP4 is a potential therapeutic target for PCa, especially CRPC.
  • Understanding PCP4's role provides insights into CRPC pathogenesis.
Keywords:
CRPCPCP4PEP-19progressionprostate cancer

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