Related Experiment Video
Updated: May 12, 2026

10:24
Ischemic Tissue Injury in the Dorsal Skinfold Chamber of the Mouse: A Skin Flap Model to Investigate Acute Persistent Ischemia
Published on: November 17, 2014
16.9K
Cryotherapy-Induced Full-Thickness Digital Frostbite Injury Reconstructed With Reverse Cross-Finger Flap
Joseph W Gorvetzian1, Jacob D Franke1, Reece A Moore1
1Michigan State University/Corewell Health Division of Plastic Surgery, Grand Rapids, MI.
Journal of Hand Surgery Global Online
|August 1, 2025
Summary
A rare case of full-thickness frostbite injury occurred after cryotherapy for a digital wart. Reconstruction with a reverse cross-finger flap led to excellent functional and cosmetic outcomes, resolving tendon injury.
Area of Science:
- Dermatology
- Plastic Surgery
- Hand Surgery
Background:
- Cryotherapy, commonly using liquid nitrogen, is a frequent treatment for viral digital warts.
- Complications from cryotherapy are rare, typically involving minor skin issues like dyspigmentation or temporary sensory disturbances.
Observation:
- A 37-year-old woman developed a full-thickness frostbite injury on her left ring finger after cryotherapy for a viral wart.
- The injury exposed and partially damaged the terminal extensor tendon.
Findings:
- The wound required debridement and reconstruction using a reverse cross-finger flap from the adjacent long finger.
- Post-operative assessment revealed excellent functional and cosmetic results.
Implications:
- This case highlights a rare but severe complication of cryotherapy for digital warts.
- Successful surgical reconstruction can restore function and appearance after extensive frostbite injuries involving tendons.

