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Pilot study evaluating lipoma reduction with injected physiologic ice slurry.

Kristen K Arango1, Cheryl A London1, William M Karlin1

  • 1Department of Clinical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, MA, United States.

Frontiers in Veterinary Science
|August 1, 2025
PubMed
Summary
This summary is machine-generated.

BXT-786 coolant injection into canine lipomas was feasible but did not reduce tumor size. Adverse events were minimal and generally unrelated to the coolant, suggesting potential for future research with modified coolant delivery.

Keywords:
caninecoolantice-slurrylipolysislipomaveterinary

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Area of Science:

  • Veterinary Medicine
  • Oncology
  • Biomaterials

Background:

  • Canine lipomas are common benign tumors.
  • Current treatment options for lipomas can be invasive or have limitations.
  • Novel therapeutic approaches are needed for effective lipoma management.

Purpose of the Study:

  • To evaluate the safety and efficacy of BXT-786 coolant injection for canine lipomas.
  • To assess the impact of BXT-786 on lipoma size and histopathology.
  • To determine the adverse event profile associated with BXT-786 treatment.

Main Methods:

  • Ten client-owned dogs with two lipomas each were enrolled.
  • Lipomas were injected with BXT-786 coolant or saline control.
  • Lipoma size, adverse events, and quality of life were monitored for 12 weeks; histopathology was performed post-excision.

Main Results:

  • BXT-786 injection was feasible, with most lipomas remaining stable in size.
  • Ultrasound showed greater variability in response assessment compared to calipers.
  • No significant changes in quality of life were observed; adverse events were mostly unrelated to BXT-786.

Conclusions:

  • BXT-786 coolant induced histopathologic changes but did not cause lipoma shrinkage.
  • Further research is needed to optimize coolant properties and delivery for enhanced tumor reduction.