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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
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Related Experiment Video

Updated: Sep 13, 2025

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
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Reply: "Target the Circuit, Not the Brain: Rethinking Essential Tremor Therapy"

Adreesh Mukherjee1, Sanjay Pandey2

  • 1Department of Neurology, North Bengal Medical College, Darjeeling, India.

Movement Disorders Clinical Practice
|August 1, 2025
PubMed
Summary

No abstract available in PubMed .

Keywords:
brain circuitessential tremortreatment

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