Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Retroviruses02:33

Retroviruses

12.7K
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
12.7K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

928
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
928
Viral Recombination00:57

Viral Recombination

23.8K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Megakaryocytes Internalize and Are Activated by Immune Complexes.

Circulation research·2026
Same author

Human herpesvirus 7 integrates into host telomeres via its telomeric repeat arrays.

PLoS pathogens·2026
Same author

A viral APOBEC3 antagonist distinguishes HHV-6A from HHV-6B.

Nature communications·2026
Same author

Assessing VirScan serosurvey epitope profiling variability between in-clinic venous blood draw and capillary blood self-sampling device.

Microbiology spectrum·2026
Same author

Engineering a Modular PapMV Nanoparticle Vaccine: Comparative Efficacy of a Covalent and a Non-Covalent N-Antigen Vaccine Against Emerging SARS-CoV-2 Variants.

Vaccines·2026
Same author

Conserved U14-Mediated NF-κB Activation in Human Herpesvirus 6A and 6B.

Microbiology and immunology·2026
Same journal

Something old, something new? Herpesvirus genome packaging examined in light of lessons from the tailed bacteriophages.

Journal of virology·2026
Same journal

Receptor profiling and growth assessment of influenza A virus in porcine mammary and non-mammary tissues and derived cells.

Journal of virology·2026
Same journal

Live human metapneumovirus vaccine candidates attenuated by temperature sensitivity mutations from human respiratory syncytial virus.

Journal of virology·2026
Same journal

Structure and functional analyses of vaccinia virus J5 protein reveal distinct determinants for entry-fusion complex assembly and activation.

Journal of virology·2026
Same journal

Coronavirus membrane protein with a fluorescent protein tag enables particle tracking for the study of virus assembly and egress in live cells.

Journal of virology·2026
Same journal

Disruption of the S1/S2 multibasic cleavage site attenuates infectious bronchitis virus, while S2' partially restores viral virulence and expands tissue tropism.

Journal of virology·2026
See all related articles

Related Experiment Video

Updated: Sep 13, 2025

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
11:56

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Published on: August 24, 2015

11.3K

Endogenous human herpesviruses 6A/B.

Louis Flamand1,2, Jesse Arbuckle3, Pascale Bonnafous4

  • 1Department of Microbiology, Infectious Disease and Immunology, Faculty of Medicine, Université Laval, Québec, Canada.

Journal of Virology
|August 1, 2025
PubMed
Summary
This summary is machine-generated.

Inherited human herpesviruses 6A/6B (eHHV-6A/B) integrate into germline DNA, passed to offspring. This viral DNA may reactivate, causing health issues, necessitating standardized terminology for clarity.

Keywords:
HHV-6eHHV-6endogenous HHV-6human herpesvirus 6iciHHV-6inherited chromosomally integrated HHV-6

More Related Videos

Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining
13:22

Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining

Published on: January 23, 2014

18.4K
Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
11:14

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

9.2K

Related Experiment Videos

Last Updated: Sep 13, 2025

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
11:56

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Published on: August 24, 2015

11.3K
Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining
13:22

Detection of the Genome and Transcripts of a Persistent DNA Virus in Neuronal Tissues by Fluorescent In situ Hybridization Combined with Immunostaining

Published on: January 23, 2014

18.4K
Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
11:14

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

9.2K

Area of Science:

  • Virology
  • Genetics
  • Human Health

Background:

  • Human herpesviruses 6A and 6B (HHV-6A/B) possess the ability to integrate into the host genome.
  • Germline integration results in inherited viral DNA, termed "endogenous HHV-6A/B (eHHV-6A/B)".
  • This inherited DNA is present in 0.2-3% of the human population and can be transmitted across generations.

Purpose of the Study:

  • To propose standardized nomenclature for HHV-6A/B integrations.
  • To differentiate between germline and somatic integrations of HHV-6A/B.

Main Methods:

  • Review of existing literature on HHV-6A/B integration.
  • Proposal of new terminology based on integration type.

Main Results:

  • Advocacy for the term "endogenous HHV-6A/B (eHHV-6A/B)" for germline-integrated HHV-6A/B.
  • Recommendation to reserve "chromosomally integrated" exclusively for somatic integrations.

Conclusions:

  • Standardized terminology is crucial to reduce confusion in research and clinical settings.
  • Clear distinction between inherited and somatic HHV-6A/B integrations is necessary for accurate health risk assessment.
  • The proposed nomenclature aims to improve communication regarding eHHV-6A/B and its potential health implications.