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Updated: Sep 13, 2025

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
Published on: May 11, 2014
Nonendoscopic Detection of Barrett's Esophagus on Patients Without Gastroesophageal Reflux Disease Symptoms
Amitabh Chak1,2,3, Komal Keerthy1, Gi-Ming Wang2
1Division of Gastroenterology and Hepatology, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Introduction:
Upper endoscopy (EGD) is generally recommended in those with chronic gastroesophageal reflux disease (GERD). To evaluate nonendoscopic screening in those without GERD symptoms.
Methods:
EsoCheck/Esoguard (LucidDx) was performed in recruited patients without chronic GERD who had ≥3 other BE risk factors.
Results:
The EsoGuard assay was positive in 34 of 120 patients. BE was identified in 9 of 27 who had follow-up EGD, positive predictive value = 33% (17%-54%). EGD performed in 22 of 86 subjects with negative assays found no BE, negative predictive value = 100% (85%-100%).
Discussion:
Nonendoscopic BE detection is effective in patients without chronic GERD.
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