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Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay
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Association between oxidative balance score and systemic immune-inflammation index: NHANES 2003-2018
Yongling Niu1, Ziyi Fan2, Zelin Wang3
1Department of Neurology, The Second Hospital of Shanxi Medical University, Taiyuan, China.
Plos One
|August 1, 2025
Summary
Higher antioxidant capacity, measured by the Oxidative Balance Score (OBS), is linked to lower inflammation, indicated by the Systemic Immune-Inflammation Index (SII). Improving antioxidant status through lifestyle choices may reduce inflammation.
Area of Science:
- Biochemistry
- Nutrition Science
- Immunology
Background:
- Oxidative stress and inflammation are interconnected processes.
- The Oxidative Balance Score (OBS) quantifies an individual's antioxidant capacity.
- The Systemic Immune-Inflammation Index (SII) is a novel inflammatory marker.
Purpose of the Study:
- To investigate the association between the Oxidative Balance Score (OBS) and the Systemic Immune-Inflammation Index (SII).
Main Methods:
- Analysis of 16,080 participants from the NHANES database (2003-2018).
- Utilized weighted multivariable linear regression, subgroup analyses, and sensitivity analyses.
- Examined linear relationships and interaction effects of age and hypertension.
Main Results:
- A significant negative association was found between higher OBS quartiles and SII (β = -51.52, P < 0.001).
- Age and hypertension significantly modified this association.
- A linear relationship between OBS and SII was confirmed (P-non-liner = 0.677).
Conclusions:
- The Oxidative Balance Score (OBS), reflecting diet and lifestyle, is strongly associated with reduced inflammation (SII).
- Enhancing antioxidant status through lifestyle modifications is crucial for lowering systemic inflammation.
