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Engineered Microbubbles for Breast Cancer Imaging and Therapy: From Material Innovation to Clinical Translation.

Sumana Halder1, Koel Chaudhury1, Subhamoy Mandal1

  • 1School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India.

ACS Applied Bio Materials
|August 1, 2025
PubMed
Summary

Microbubbles offer advanced ultrasound imaging and therapy for breast cancer detection and treatment. This review highlights recent material-driven innovations in microbubble contrast agents for improved breast cancer theranostics.

Keywords:
breast cancercontrast agentsmicrobubbletheranosticsultrasound

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Area of Science:

  • Biomaterials Science
  • Medical Imaging
  • Oncology

Background:

  • Breast cancer necessitates improved diagnostic and therapeutic methods beyond conventional treatments.
  • Microbubble-based ultrasound contrast agents present a promising portable, real-time imaging and targeted therapy approach.
  • Existing literature lacks a comprehensive review of recent microbubble advancements in breast cancer management.

Purpose of the Study:

  • To review recent advancements (2019-2024) in microbubble-based ultrasound contrast agents for breast cancer diagnosis and therapy.
  • To discuss emerging agents like nanobubbles and nanodroplets with similar utility.
  • To examine contrast agent design, fabrication, and interaction mechanisms with breast tissue.

Main Methods:

  • Methodological review of preclinical studies and clinical trials.
  • Analysis of material and structural properties of microbubble contrast agents.
  • Examination of recent literature on ultrasound contrast agents for breast cancer theranostics.

Main Results:

  • Microbubble ultrasound agents show efficacy in preclinical and clinical settings for breast cancer diagnosis and therapy.
  • Recent innovations focus on engineered contrast agents with targeted therapeutic capabilities.
  • Nanobubbles and nanodroplets are emerging as viable alternatives with similar applications.

Conclusions:

  • Microbubble-based ultrasound theranostics represent a significant advancement in breast cancer management.
  • Material-driven innovations are key to developing more effective diagnostic and therapeutic solutions.
  • This review serves as a resource for researchers and clinicians advancing breast cancer theranostics.