Related Experiment Video

Updated: Sep 13, 2025

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

19.7K

Computed Tomography-Derived Extracellular Volume Fraction in Non-ST-Segment Elevation Myocardial Infarction With

Tatsuhiro Nagamine1, Yoshihisa Kanaji1, Eisuke Usui1

  • 1Department of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.

JACC. Case Reports
|August 1, 2025
PubMed

Insights

Identifying the infarct-related artery in non-ST-segment elevation myocardial infarction (NSTEMI) is challenging. Computed tomography-based ECV mapping can pinpoint ischemic injury, aiding in diagnosis and treatment.

Area of Science:

  • Cardiovascular Imaging
  • Radiology
  • Myocardial Infarction Research

Background:

  • Accurate identification of the infarct-related artery (IRA) in non-ST-segment elevation myocardial infarction (NSTEMI) is crucial, especially in patients with multivessel disease.
  • Current diagnostic methods face challenges in precisely localizing the IRA in complex coronary anatomies.

Observation:

  • A case study involving an 88-year-old male with NSTEMI demonstrated intermediate-to-severe stenoses in multiple coronary arteries via coronary computed tomography angiography (CCTA).
  • CCTA-derived extracellular volume (ECV) fraction analysis revealed a regional elevation in the mid-anterolateral wall, correlating with the diagonal branch territory.

Findings:

  • The elevated ECV fraction in the affected myocardial region suggests acute inflammation and edema.
  • This finding indicates that computed tomography-based ECV mapping can effectively localize acute ischemic injury, even in the presence of multivessel disease.

Implications:

  • CCTA-derived ECV fraction assessment may significantly improve IRA determination in NSTEMI patients.
  • This technique holds the potential to guide targeted revascularization strategies and reduce diagnostic uncertainty in complex cardiovascular cases.
Abstract

Keywords:
coronary computed tomography angiographyextracellular volume fractionnon–ST-segment elevation myocardial infarction

More Related Videos

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease12:15

Tissue Preparation Techniques for Contrast-Enhanced Micro Computed Tomography Imaging of Large Mammalian Cardiac Models with Chronic Disease

Published on: February 8, 2022

2.6K
Histological Quantification of Chronic Myocardial Infarct in Rats09:45

Histological Quantification of Chronic Myocardial Infarct in Rats

Published on: December 11, 2016

14.8K

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
119
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
66
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
137