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Updated: Sep 13, 2025

Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

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Radial Approach Renal Denervation: A First-in-Man Case With the 4-F TIVUS Catheter.

Ortal Tuvali¹, Alex Blatt¹, Gabby Elbaz-Greener²

¹The Heart Institute, Kaplan Medical Center, Hebrew University, Jerusalem, Israel.

JACC. Case Reports

|August 1, 2025

Summary

Transradial renal denervation (RDN) using a novel ultrasound catheter is a safe and feasible treatment for resistant hypertension. This approach may reduce complications and allow for same-day discharge.

Keywords:

case report hypertension radial approach renal denervation ultrasound ablation vascular access

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Area of Science:

Cardiovascular medicine
Interventional cardiology
Hypertension management

Background:

Renal denervation (RDN) effectively treats uncontrolled hypertension, commonly using femoral access.
Vascular complications are the most frequent adverse events associated with RDN procedures.

Observation:

A 57-year-old male with resistant hypertension underwent bilateral RDN.
A novel 4-F ultrasound catheter was utilized via left radial arterial access in the REDUCED 1 clinical study.

Findings:

The transradial RDN procedure was uneventful.
Significant reductions in both ambulatory and office blood pressure were observed at 3-month follow-up.

Implications:

Transradial RDN with this ultrasound catheter is feasible and safe.
The radial approach may decrease access-site complications and facilitate same-day patient discharge.
Further research is warranted to validate the benefits of this transradial system.