Related Experiment Video
Updated: Sep 13, 2025
Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
Published on: September 13, 2019
RUNX1::RUNX1T1 Positive Acute Myeloid Leukemia Secondary to Isolated Breast Myeloid Sarcoma: A Case Report and
Gui-Rui Sang1, Chun-Li Xu2,3, Dong-Ping Huang4
1Department of Endocrinology, the Second Affiliated Hospital of Wannan Medical College, Wuhu, China.
Objective:
Isolated Myeloid sarcoma (IMS) of breast is extremely rare and current treatment approaches for Acute Myeloid Leukemia (AML) secondary to breast IMS are even rarer. It is worthwhile to explore the clinical features of this disease and the promising treatment strategy.
Case Report:
We described one case of IMS that occurred in the breast in a 37-year-old female, who progressed to RUNX1::RUNX1T1 positive AML in less than two years. Then, she was treated with Venetoclax plus hypomethylating agents, which showed favorable response.
Discussion:
She has remained in complete remission (CR) to date after the Venetoclax-based treatment.
Conclusions:
Breast IMS is rare but highly progressive to AML. Imaging and histopathology are key tools in diagnosing it and Venetoclax-based regimens may be a promising treatment strategy.
More Related Videos
09:16Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
Published on: September 1, 2019
13:41Magnetic Resonance-Guided High Intensity Focused Ultrasound Generated Hyperthermia: A Feasible Treatment Method in a Murine Rhabdomyosarcoma Model
Published on: January 13, 2023
Related Concept Videos
01:03Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
02:23Abnormal Proliferation