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Related Concept Videos

Diffusion01:12

Diffusion

219.2K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
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Diffusion01:21

Diffusion

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Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
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Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

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Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
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Primary Active Transport01:47

Primary Active Transport

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In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps that are embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction...
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Facilitated Diffusion01:16

Facilitated Diffusion

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The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Related Experiment Video

Updated: Feb 5, 2026

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
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Clinical Analysis of Primary Prostatic Diffuse Large B-Cell Lymphoma.

Shao-Juan Cui1, Hang Yin1, Qiong Liu1

  • 1Department of Hematology, the Second Affiliated Hospital of Wannan Medical College, Wuhu, China.

Annals of Clinical and Laboratory Science
|February 3, 2026
PubMed
Summary

Primary diffuse large B-cell lymphoma of the prostate (P-DLBCL-P) is rare and challenging to diagnose. This case series highlights diagnostic difficulties and poor outcomes despite timely diagnosis and treatment.

Keywords:
Diffuse large B-Cell lymphomapathological examinationprostate lymphoma

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Area of Science:

  • Oncology
  • Urology
  • Pathology

Background:

  • Primary diffuse large B-cell lymphoma of the prostate (P-DLBCL-P) is exceptionally rare.
  • Limited case accumulation poses diagnostic and therapeutic challenges.

Purpose of the Study:

  • To investigate the clinical manifestations of P-DLBCL-P.
  • To explore potential therapeutic strategies for this rare condition.

Main Methods:

  • Presentation of three histopathologically confirmed cases of P-DLBCL-P.
  • Patients presented with lower urinary tract obstruction symptoms.

Main Results:

  • All three patients were diagnosed with P-DLBCL-P.
  • Outcomes were poor: one patient refused treatment, and two progressed despite chemotherapy (R-CDOP) or supportive care, succumbing to complications like rectovesical fistula or obstructive nephropathy.

Conclusions:

  • P-DLBCL-P is prone to misdiagnosis, necessitating attention to clinical signs.
  • Prompt diagnosis was achieved, but treatment efficacy remains limited, underscoring the need for more data on prognosis and novel therapies.