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Application of Nucleic Acid Medicine Using Autologous Serum-derived Small Extracellular Vesicles for Cancer
Mai Hazekawa1, Takuya Nishinakagawa2, Daisuke Ishibashi2
1Department of Drug Delivery, Faculty of Pharmaceutical Science, Fukuoka University, Fukuoka, Japan; mhaze@fukuoka-u.ac.jp.
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Nucleic acids are highly unstable in vivo due to their physicochemical properties, presenting a major obstacle to their clinical application as therapeutics. Consequently, the development of drug delivery systems (DDS) is essential to enable stable transport of nucleic acids within the body and to promote efficient cellular uptake. In cancer therapy in particular, selective delivery technologies capable of targeting diseased organs or tumor cells are critical for minimizing off-target effects and reducing adverse events.
