Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene-Environment Interactions01:20

Gene-Environment Interactions

440
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
440
Environmental Influences on Intelligence01:29

Environmental Influences on Intelligence

415
Despite the strong genetic influence on traits like intelligence, environmental factors significantly shape outcomes. For example, while over 90% of height variation is due to genetic differences, environmental factors such as nutrition also have a notable impact. Similarly, for intelligence, changes in a child's surroundings can significantly alter their IQ. Research shows that enriched environments boost children's academic success and help them develop key cognitive skills. Children...
415
Strategies for Assessing and Addressing Confounding01:25

Strategies for Assessing and Addressing Confounding

155
Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
155
Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

86
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
86
Environmental Applications of Microorganisms01:30

Environmental Applications of Microorganisms

248
Microorganisms play a pivotal role in maintaining ecosystem balance by recycling essential elements such as carbon, nitrogen, and phosphorus, as well as supporting processes like bioremediation, wastewater treatment, and biofuel production.Microbes in Elemental CyclesIn the carbon cycle, microorganisms decompose organic matter, releasing carbon dioxide via aerobic respiration. This carbon dioxide is subsequently used by photosynthetic organisms to synthesize organic compounds, closing the...
248
Types of Toxins01:36

Types of Toxins

2.0K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GLORIF1, a global river flow dataset created by integrating process-based modelling and machine learning.

Scientific data·2026
Same author

Harmonized Europe-wide road traffic noise modeling using CNOSSOS-EU: beyond END and agreement analysis with national models.

Environmental research·2026
Same author

The use of single and multiple pollutant models in health impact assessment of air pollution: What difference does it make and where?

Environment international·2026
Same author

Transportation noise in relation to depression and dementia: A burden of disease study for Europe.

Environmental research·2026
Same author

Air pollution and mortality across socioeconomic groups in the Netherlands.

Environment international·2026
Same author

Integrating noise as a risk factor in studies of Alzheimer's disease and dementia: Guidance for epidemiologic research.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

The combined impact of chemical and non-chemical stressors on adverse health outcomes: an overview of reviews from the epidemiological literature and experimental animal studies.

Journal of exposure science & environmental epidemiology·2026
Same journal

Diet and mycoestrogen exposure in a pregnancy cohort: the Jersey Babies pilot study.

Journal of exposure science & environmental epidemiology·2026
Same journal

Source apportionment of fine particulate matter (PM<sub>2.5</sub>) personal exposures: findings from the Household Air Pollution Intervention Network (HAPIN) study in rural Guatemala.

Journal of exposure science & environmental epidemiology·2026
Same journal

The impact of geomagnetic disturbances on mortality from respiratory tract infections in the USA, 2000-2019.

Journal of exposure science & environmental epidemiology·2026
Same journal

Metabolome-wide association study identifies metabolites associated with human exposure to perfluoroalkyl substances.

Journal of exposure science & environmental epidemiology·2026
Same journal

Contribution of non-dietary indoor exposure pathways to total phthalate intake of 324 children in Tianjin, China.

Journal of exposure science & environmental epidemiology·2026
See all related articles

Related Experiment Video

Updated: Sep 13, 2025

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
09:50

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke

Published on: February 12, 2015

11.3K

A computational framework for agent-based assessment of multiple environmental exposures.

Oliver Schmitz1, Kees de Hoogh2,3, Nicole Probst-Hensch2,3

  • 1Department of Physical Geography, Faculty of Geosciences, Utrecht University, Utrecht, The Netherlands. o.schmitz@uu.nl.

Journal of Exposure Science & Environmental Epidemiology
|August 1, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces an agent-based framework for assessing personal environmental exposure in large populations, improving accuracy by considering individual mobility. The developed software provides a reusable, open-source solution for large-scale cohort studies.

Keywords:
Activity-based modelingAir pollutionNoisePersonal exposuresUncertainty estimation

More Related Videos

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks
04:53

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks

Published on: May 26, 2023

1.3K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

473

Related Experiment Videos

Last Updated: Sep 13, 2025

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
09:50

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke

Published on: February 12, 2015

11.3K
Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks
04:53

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks

Published on: May 26, 2023

1.3K
Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans
08:14

Ecotoxicological Methodologies to Evaluate Biomarkers at Different Scales in Neotropical Anurans

Published on: April 28, 2023

473

Area of Science:

  • Environmental Health Sciences
  • Exposure Science
  • Computational Epidemiology

Background:

  • Long-term personal exposure assessment requires accounting for spatio-temporal variations in environmental factors along individual activity paths.
  • Nationwide studies necessitate integrating large datasets on environmental factors, personal behavior, and socio-economic status, including uncertainty propagation.

Purpose of the Study:

  • To develop and demonstrate a methodology for agent-based personal exposure assessment suitable for large cohorts.
  • To create a software framework for this methodology, incorporating uncertainty assessment.

Main Methods:

  • An agent-based methodology was designed to handle sparse individual activity pattern data in large cohorts.
  • A Python-based, open-source framework was developed and applied to assess air pollution and noise exposure for over 600,000 addresses.
  • Uncertainty was quantified using probability distributions and propagated via Monte Carlo simulation.

Main Results:

  • The framework aggregates time based on movement patterns (e.g., weekdays, weekend days) and represents movement as sequences of activities with spatial and temporal contexts.
  • Personal exposures calculated by the framework showed minor to moderate differences compared to home-based assessments (e.g., r²=0.79 for noise, r²=0.98 for NO₂ and PM₂.₅ in Utrecht).
  • The agent-based approach led to reduced contrast in population-wide exposures compared to traditional methods.

Conclusions:

  • Residential-based exposure assessment in epidemiological studies inadequately captures individual mobility and spatial variations in environmental concentrations.
  • Activity-based methods are needed but face implementation challenges due to a lack of conceptual frameworks and software for large cohorts.
  • The presented reusable, open-source software framework addresses these limitations, enabling consistent application across diverse environmental factors and cohort studies.