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Updated: Sep 13, 2025

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gem-Difluoroalkenes as C1 Building Blocks: Iron-Catalyzed Synthesis of Trisubstituted 2-Aroyl-1,3,5-Triazines
Yang Feng1, Xiang He1, Yanpeng Zhang1
1Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, People's Republic of China.
Abstract:
Herein, a cost-effective iron-catalyzed cascade annulation strategy of amidines that leverages readily available gem-difluoroalkenes as versatile C1 synthons is described. This innovative protocol enables the simultaneous formation of three C-N bonds and one C-O bond in a single catalytic system, delivering structurally diverse 2-aroyl-1,3,5-triazines with isolated yields up to 85%. The system exhibits broad functional group compatibility and efficient construction of triazine derivatives. Mechanistic studies suggest two plausible pathways are involved in this one-pot reaction.
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