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Updated: Sep 17, 2025
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Constructing Ar-O-P Scaffolds through Copper-Catalyzed Cleavage of the C-P Bond in BrCF2PO(OEt)2
Xi Zhang1, Chengxian Hu1, Lu Wang1
1Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, P.R. China.
Abstract:
The first example of BrCF2PO(OEt)2 as a phosphorylation reagent via copper-catalyzed cleavage of the C-P bond to synthesize phosphate ester products featuring Ar-O-P scaffolds from 2-phenylphenols has been developed. This protocol represents a significant departure from the conventional reactions involving BrCF2PO(OEt)2 in the realm of organic chemistry. Various aryl phosphate esters were prepared in up to 91% yield with exclusive chemoselectivity because no byproducts involving difluorocarbene were found. The reaction mechanism entangled diethyl iodophosphonate as a key intermediate was proposed.
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