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Cedecea infections in humans - A narrative review
Sofia Maraki1, Viktoria Eirini Mavromanolaki2, Evangelia Iliaki-Giannakoudaki1
1Department of Clinical Microbiology and Microbial Pathogenesis, University Hospital of Heraklion, PC 71110, Crete, Greece.
Diagnostic Microbiology and Infectious Disease
|August 2, 2025
Summary
Cedecea bacteria rarely cause human infections, often in immunocompromised individuals. Awareness of their antibiotic resistance is crucial for effective treatment and improved patient outcomes.
Area of Science:
- Microbiology
- Infectious Diseases
- Clinical Medicine
Background:
- Cedecea are rare Gram-negative bacteria within the Enterobacteriaceae family.
- Human infections are infrequent, typically affecting immunocompromised patients with serious underlying conditions.
Purpose of the Study:
- To review and analyze all documented human infections caused by Cedecea species.
- To understand the epidemiology, clinical characteristics, and microbiological features of Cedecea infections.
Main Methods:
- Systematic literature search of PubMed and Scopus databases.
- Inclusion of studies reporting on Cedecea epidemiology, clinical features, and microbiology.
- Analysis of 49 studies involving 50 patients.
Main Results:
- Most infections (88%) occurred in patients with comorbidities; common types included bacteremia, respiratory, soft tissue, and urinary tract infections.
- Cedecea lapagei was the most frequent species. High antibiotic resistance rates were observed for ampicillin, gentamicin, and others.
- Most patients (87.8%) had favorable outcomes, with a 10.2% mortality rate.
Conclusions:
- Cedecea species are an emerging cause of infection, particularly healthcare-associated.
- Physicians must recognize Cedecea's potential for antibiotic resistance.
- Tailoring antimicrobial therapy based on susceptibility testing is vital for optimal patient management.
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