Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

5.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.1K
The Thyroid Gland01:23

The Thyroid Gland

4.4K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.4K
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

119
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
119
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

3.2K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.2K
Relative Risk01:12

Relative Risk

347
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
347

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of an automated, imaging-based preoperative screening model for early identification of malnutrition in an abdominal surgery cohort.

medRxiv : the preprint server for health sciences·2026
Same author

ASO Visual Abstract: Comparing Resident Team Performance in Complex Surgical Oncology: A Single-Institution Cohort Study.

Annals of surgical oncology·2026
Same author

Non-interruptive decision support to increase appropriate screening for primary hyperparathyroidism.

American journal of surgery·2026
Same author

Genetic Susceptibility to Incisional Hernia Evaluation of Hernia Polygenic Risk Scores.

medRxiv : the preprint server for health sciences·2026
Same author

Comparing Resident Team Performance in Complex Surgical Oncology: A Single-Institution Cohort Study.

Annals of surgical oncology·2026
Same author

Patient Outcome Reports for Senior Residents: An Opportunity to Foster Reflection and Identify Outliers for Intervention.

Journal of surgical education·2026

Related Experiment Video

Updated: Sep 13, 2025

Mixed Reality Assisted Radical Endoscopic Thyroidectomy
08:06

Mixed Reality Assisted Radical Endoscopic Thyroidectomy

Published on: January 31, 2025

405

A Clinical Risk Score for Thyroid Hormone Therapy After Partial Thyroidectomy.

Elias Mimouni1, Jesse E Passman1, Maya Alexis1

  • 1Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.

The Journal of Surgical Research
|August 3, 2025
PubMed
Summary

A new clinical risk score predicts levothyroxine (LT4) needs after partial thyroidectomy. Factors like TSH and race help estimate LT4 therapy requirements, aiding patient counseling and surgical decisions.

Keywords:
HypothyroidismLT4Partial thyroidectomyRisk scoreThyroid hormone supplementThyroid nodule

More Related Videos

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
04:01

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

922
Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
04:09

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter

Published on: September 20, 2024

408

Related Experiment Videos

Last Updated: Sep 13, 2025

Mixed Reality Assisted Radical Endoscopic Thyroidectomy
08:06

Mixed Reality Assisted Radical Endoscopic Thyroidectomy

Published on: January 31, 2025

405
Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma
04:01

Transoral Robotic Total Thyroidectomy and Bilateral Central Regional Lymph Node Dissection for Papillary Thyroid Carcinoma

Published on: September 15, 2023

922
Minimal Invasive Resection of Large Retrosternal Thyroid Goiter
04:09

Minimal Invasive Resection of Large Retrosternal Thyroid Goiter

Published on: September 20, 2024

408

Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Clinical Risk Prediction

Background:

  • Partial thyroidectomy necessitates individualized thyroid hormone therapy (levothyroxine [LT4]) decisions.
  • Preoperative factors like thyroid stimulating hormone (TSH) levels and diagnosis influence LT4 requirements.

Purpose of the Study:

  • To develop a user-friendly clinical risk score for predicting the need for LT4 therapy post-partial thyroidectomy.
  • To enhance clinical decision-making regarding postoperative thyroid hormone management.

Main Methods:

  • Retrospective cohort study of 425 patients undergoing partial thyroidectomy (2013-2020).
  • Logistic regression and lasso regression identified significant predictors of LT4 therapy.
  • A weighted clinical risk score was developed using significant covariates.

Main Results:

  • 41.9% of patients required LT4 therapy post-surgery.
  • Key predictors for LT4 therapy included non-Black race, preoperative TSH ≥1.59 uIU/mL, and cancer diagnosis.
  • LT4 use increased with higher risk score points, demonstrating predictive accuracy.

Conclusions:

  • A simple, health record-derivable risk score effectively predicts LT4 needs after partial thyroidectomy.
  • This tool can guide patient counseling and surgical extent discussions for thyroid nodules.
  • The risk score aids in personalized postoperative thyroid hormone management.