Related Experiment Video
Updated: Jul 11, 2026

Prediction of HIV-1 Coreceptor Usage Tropism by Sequence Analysis using a Genotypic Approach
Published on: December 1, 2011
Tenofovir diphosphate concentrations in dried blood spots predict future HIV suppression but not virologic failure in
Sampson Antwi1,2, Hongmei Yang3, Anthony Enimil1,2
1Department of Child Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi.
Abstract:
We investigated whether tenofovir diphosphate (TFV-DP) concentration in dried blood spot (DBS) predicted future virologic outcome. Of 52 adolescents with HIV, 46% had virologic suppression, and 44% had virologic failure. TFV-DP concentration in DBS was associated with virologic suppression but not virologic failure. Twenty-six percentage of participants with virologic failure had high levels of antiretroviral adherence at earlier visits. Virologic failure in the setting of high adherence may suggest the presence of HIV drug resistance.
Related Concept Videos
Retrovirus Life Cycles
Pharmacokinetics in Pediatric Patients: Drug Excretion

