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Mesenchymal stem cell application in Alzheimer's disease.

Qianying Feng¹, Fengxia Chen¹, Rui Liu¹

¹Nursing School, North Henan Medical University, Xinxiang, 453003, China.

Regenerative Therapy

|August 4, 2025

Summary

Mesenchymal stem cell therapy shows promise for Alzheimer's disease (AD) by aiding tissue repair and stimulating healing. This review explores its preclinical and clinical uses, mechanisms, and limitations for treating neurodegenerative conditions.

Keywords:

Alzheimer's disease Clinical applications Mesenchymal stem cells Preclinical application Underlying mechanisms

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Area of Science:

Neuroscience
Regenerative Medicine
Gerontology

Background:

Alzheimer's disease (AD) is a progressive neurodegenerative disorder impacting cognitive and physical functions in older adults.
Key symptoms include memory loss, aphasia, dementia, and visual-spatial impairment.
Current treatments for AD are limited, necessitating exploration of novel therapeutic approaches.

Purpose of the Study:

To review the preclinical and clinical applications of mesenchymal stem cells (MSCs) in Alzheimer's disease.
To elucidate the underlying mechanisms of MSCs in AD treatment.
To identify limitations and potential solutions for MSC therapy in AD.

Main Methods:

Comprehensive literature review of preclinical studies and clinical trials involving MSCs for AD.
Analysis of research on MSC mechanisms of action, including neuroprotection and immunomodulation.
Evaluation of current challenges and future directions for MSC-based therapies.

Main Results:

MSCs demonstrate potential in preclinical models of AD, showing neuroprotective and anti-inflammatory effects.
Clinical applications are emerging, with ongoing trials investigating safety and efficacy.
Mechanisms involve paracrine signaling, immunomodulation, and direct cell replacement or support.

Conclusions:

Mesenchymal stem cell therapy is a promising regenerative approach for Alzheimer's disease.
Further research is needed to overcome application limitations and optimize therapeutic strategies.
MSC therapy offers a potential foundation for future Alzheimer's disease treatment development.