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Infections Associated with the Streptococcus Anginosus Group in Children

Isil Ezel Taskin Karacay1, Gulsum Iclal Bayhan2, Tugba Erat1

  • 1Department of Pediatric Infectious Disease, Ankara Bilkent City Hospital, Ankara, Türkiye.

Sisli Etfal Hastanesi Tip Bulteni
|August 4, 2025
PubMed

Insights

The Streptococcus anginosus group (SAG) causes various infections in children, with Streptococcus constellatus being the most common. Skin and soft tissue infections were most frequent, often requiring surgical drainage.

Area of Science:

  • Pediatric Infectious Diseases
  • Microbiology
  • Clinical Medicine

Background:

  • The Streptococcus anginosus group (SAG), including S. anginosus, S. intermedius, and S. constellatus, are known pathogens.
  • SAG infections commonly manifest as skin, soft tissue, intra-abdominal, skeletal, and ENT/cervical infections.
  • Evaluating SAG infections specifically in pediatric populations is crucial for understanding disease patterns.

Purpose of the Study:

  • To investigate the clinical characteristics and outcomes of infections caused by the Streptococcus anginosus group in children.
  • To identify the most prevalent SAG species and infection sites in pediatric patients.
  • To determine the need for surgical intervention and the incidence of bacteremia in this cohort.

Main Methods:

  • A retrospective review of pediatric patients (0-18 years) with positive cultures for SAG species between January 2019 and March 2024.
  • Analysis of patient demographics, clinical presentations, isolated SAG species, and treatment modalities.
  • Documentation of predisposing factors, surgical drainage requirements, and occurrence of bacteremia.

Main Results:

  • 113 patients had positive SAG cultures, with 93 confirmed infections.
  • Streptococcus constellatus (49.5%) was the most common species, followed by S. anginosus (38.7%) and S. intermedius (11.8%).
  • Skin and soft tissue infections (63 patients) were most prevalent, with 74.4% requiring surgical drainage; S. intermedius was more common in deep tissue infections.

Conclusions:

  • Streptococcus constellatus is the predominant SAG species causing infections in children.
  • Skin and soft tissue infections are the most common presentation, frequently necessitating surgical drainage.
  • The incidence of bacteremia in pediatric SAG infections is low, but S. intermedius may indicate deeper infections.
Abstract

Keywords:
AbscessStreptococcus anginosus groupskin and soft tissuesurgical drainage

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