Neuropsychiatric disorders in Parkinson's disease
Beatrice Heim1, Atbin Djamshidian2
1Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
Therapeutic Advances in Neurological Disorders
|August 4, 2025
Summary
Neuropsychiatric symptoms are common in Parkinson's disease (PD) and impulse control disorders. This review outlines treatments to improve patient quality of life.
Area of Science:
- Neurology
- Psychiatry
Background:
- Neuropsychiatric symptoms like depression, anxiety, and cognitive changes are prevalent in Parkinson's disease (PD).
- These symptoms can manifest at any disease stage, sometimes preceding diagnosis, and often worsen with PD progression, especially during 'off-periods'.
- Impulse control disorders, characterized by low insight, also frequently present with neuropsychiatric symptoms.
Purpose of the Study:
- To review non-pharmacological, experimental, and pragmatic pharmacological treatment strategies for neuropsychiatric symptoms in Parkinson's disease.
- To enhance understanding of optimal treatment approaches for patients experiencing these complex symptoms.
Main Methods:
- This study is a narrative review of existing literature.
- It synthesizes information on various therapeutic interventions for neuropsychiatric symptoms in PD.
Main Results:
- Neuropsychiatric symptoms significantly impact Parkinson's disease patients, affecting quality of life.
- Effective management requires a comprehensive approach, considering both disease progression and co-occurring disorders.
Conclusions:
- Early detection and a tailored, multidisciplinary approach are crucial for managing neuropsychiatric symptoms in Parkinson's disease.
- Improving symptom management can significantly enhance the quality of life for patients and their families.
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