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RNF144A and RNF144B: Important molecules for health.

Wang Jiang1, Yi Liang2, Min Han3

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RNF144A and RNF144B are ubiquitin E3 ligases regulating protein ubiquitination. This review synthesizes their molecular mechanisms and roles in disease, highlighting knowledge gaps for future research.

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Area of Science:

  • Biochemistry and Molecular Biology
  • Cellular Biology
  • Pathophysiology

Background:

  • RNF144 family proteins (RNF144A, RNF144B) are RING-between-RING ubiquitin E3 ligases.
  • These proteins are crucial regulators of protein ubiquitination.
  • Existing research highlights their distinct roles in disease, but a comprehensive synthesis is lacking.

Purpose of the Study:

  • To systematically review and synthesize current knowledge on RNF144A/B.
  • To elucidate their molecular mechanisms and pathophysiological significance across diseases.
  • To identify knowledge gaps and therapeutic potential.

Main Methods:

  • Systematic literature search on PubMed using keywords: "RNF144," "RNF144A," "RNF144B," "PIR2," "IBRDC2," "P53RFP."
  • Critical analysis of structural characteristics, substrate interactions, and signaling pathways.
  • Review of evidence across various disease systems.

Main Results:

  • RNF144A/B play dual roles in maintaining cellular homeostasis and contributing to disease pathogenesis.
  • Evidence regarding their specific molecular functions and substrate interactions is consolidated.
  • Distinct pathophysiological roles across different disease contexts are examined.

Conclusions:

  • This review consolidates current understanding of RNF144A/B functions and disease relevance.
  • Key knowledge gaps, including isoform-specific functions, require further investigation.
  • Potential for therapeutic targeting of RNF144A/B in disease is highlighted.