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Pyoderma gangrenosum associated with major adverse cardiovascular events
Nana Ama Adjei-Frimpong1, Francesco Delacqua2, Ben A Croker3
1Department of Dermatology, University of California San Diego, San Diego, CA, U.S.A.
Pyoderma gangrenosum (PG) is linked to a higher risk of major adverse cardiovascular events (MACE). This study confirms this association in a US population, emphasizing the need for cardiovascular screening in PG patients.
Area of Science:
- Cardiology
- Dermatology
- Epidemiology
Background:
- Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis causing painful ulcers.
- Previous studies suggested a link between PG and major adverse cardiovascular events (MACE), but lacked robust controls and US data.
- This research addresses these limitations by utilizing a US-based, diverse population dataset.
Purpose of the Study:
- To investigate the association between pyoderma gangrenosum (PG) and major adverse cardiovascular events (MACE) in a US population.
- To leverage the All of Us (AoU) database for a comprehensive analysis.
- To provide evidence for improved cardiovascular risk assessment in PG patients.
Main Methods:
- A nested case-control study was conducted using the All of Us (AoU) database (May 2018 - March 2025).
- Pyoderma gangrenosum (PG) cases were identified using SNOMED codes and matched 4:1 to controls.
- Logistic regression analysis assessed the association between PG and MACE, adjusting for key comorbidities.
Main Results:
- The study identified 579 cases of pyoderma gangrenosum (PG).
- A significant association was found between PG and major adverse cardiovascular events (MACE) (OR, 2.19; 95% CI, 1.47-3.27; p<.001).
- This association remained significant after multivariable adjustment.
Conclusions:
- Pyoderma gangrenosum (PG) is independently associated with increased odds of major adverse cardiovascular events (MACE) in a US cohort.
- These findings underscore the necessity of cardiovascular screening and proactive risk management for patients with PG.
- Further research into the underlying pathophysiological mechanisms is warranted to guide targeted treatment strategies.
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