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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
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Acute Kidney Injury (AKI) in Adults With Leukemia: A Nationwide Inpatient Retrospective Analysis
Barath P Sivasubramanian1, Sindhu C Pokhriyal2, Shashvat Joshi3
1Department of Internal Medicine, Northeast Georgia Medical Center, Gainesville, GA, USA.
Journal of Community Hospital Internal Medicine Perspectives
|August 4, 2025
Summary
Acute Kidney Injury (AKI) in leukemia patients has lower mortality, but severe sepsis, thrombocytopenia, and metabolic encephalopathy significantly increase risks. Managing AKI requires careful antibiotic selection and bone marrow evaluation.
Area of Science:
- Oncology
- Nephrology
- Hematology
Background:
- Leukemia is a leading cancer associated with Acute Kidney Injury (AKI).
- AKI occurs in 7.5% of hematological malignancy patients.
- This study investigates mortality factors in leukemia patients with AKI.
Purpose of the Study:
- To assess the mortality associated with severe sepsis (SS), thrombocytopenia, and metabolic encephalopathy (MetE) in leukemia patients with AKI.
- To identify risk factors for mortality in this patient cohort.
Main Methods:
- Retrospective analysis of the National Inpatient Sample (2018-2021).
- Inclusion of adult leukemia patients primarily admitted with AKI.
- Stratification by SS, thrombocytopenia, and MetE, with propensity matching and multivariate regression.
Main Results:
- Leukemia patients with AKI had lower mortality risk (aOR 0.04) compared to those without AKI.
- Increased mortality was observed in patients >60 years old (p < 0.001).
- Severe sepsis (aOR 38.2), thrombocytopenia (aOR 1.8), and metabolic encephalopathy (aOR 3.3) significantly increased mortality risk (p < 0.001).
Conclusions:
- AKI in leukemia patients demonstrates lower mortality, but comorbidities like severe sepsis, thrombocytopenia, and metabolic encephalopathy elevate mortality rates.
- Effective management of AKI in leukemia necessitates judicious antibiotic choices and comprehensive assessment of bone marrow status.
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