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Hand hygiene

Hand hygiene

Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
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Updated: Sep 12, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

A Rare, Cephalosporin-induced Rash: Acute Generalized Exanthematous Pustulosis.

Mark A Colantonio¹, Danielle Sblendorio², Elizabeth Hart¹

¹Department of Medicine, West Virginia University, PO Box 9168, Department of Medicine House Staff, 4 Floor HSC-N Morgantown, Morgantown, WV 26506, USA.

Journal of Community Hospital Internal Medicine Perspectives

|August 4, 2025

Summary

This summary is machine-generated.

Acute generalized exanthematous pustulosis (AGEP) is a rare rash caused by medications. This case highlights cephalosporins as an uncommon cause of AGEP, emphasizing the need for increased awareness in clinical practice.

Keywords:

Acute generalized exanthematous pustulosis Cephalosporins Penicillin Toxic epidermal necrolysis

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Last Updated: Sep 12, 2025

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Area of Science:

Dermatology
Pharmacovigilance

Background:

Acute generalized exanthematous pustulosis (AGEP) is a rare, severe cutaneous adverse reaction.
It is typically characterized by widespread pustules on an erythematous base and subsequent peeling.
Medications are the most common triggers, with antibiotics frequently implicated.

Observation:

This report details a rare case of AGEP in a rural healthcare setting.
The patient developed the characteristic rash following recent cephalosporin antibiotic use.
Cephalosporins are infrequently reported as causative agents for AGEP.

Findings:

The patient presented with classic symptoms of AGEP, including pustules and erythema.
Cessation of cephalosporin therapy led to symptom resolution.
This case underscores the potential for cephalosporins to induce AGEP.

Implications:

Highlights the importance of considering cephalosporins in the differential diagnosis of drug-induced rashes.
Emphasizes the need for heightened clinical awareness of AGEP triggers, even rare ones.
Contributes to pharmacovigilance data on cephalosporin-associated adverse drug reactions.