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Voriconazole-induced photosensitivity and cheilitis
Mrinal Kanti Das1, Krishna Deb Barman1, Ananya Sharma1
1Department of Dermatology and Venereology, Maulana Azad Medical College, New Delhi, India.
The Journal of the Royal College of Physicians of Edinburgh
|August 4, 2025
Summary
Voriconazole treatment for invasive aspergillosis can cause photosensitivity and skin changes. Patient education on these side effects is crucial to prevent complications like skin cancer.
Area of Science:
- Mycology
- Dermatology
- Pharmacology
Background:
- Invasive aspergillosis is a serious fungal infection.
- Voriconazole is a key antifungal medication.
- Adverse drug reactions require careful monitoring.
Purpose of the Study:
- To report a case of voriconazole-induced photosensitivity and hyperpigmentation.
- To highlight the importance of patient education regarding voriconazole side effects.
Main Methods:
- Case report of a middle-aged man with invasive aspergillosis.
- Treatment with oral voriconazole.
- Observation of dermatological side effects after 4 months.
Main Results:
- The patient developed photosensitivity, cracked lips, and dark-brown facial and truncal hyperpigmentation.
- Photosensitivity affects 10%-20% of patients on voriconazole.
- Potential for voriconazole-induced photosensitivity to lead to cutaneous malignancies.
Conclusions:
- Voriconazole can cause significant phototoxic reactions.
- Early patient education on phototoxicity is essential for managing voriconazole therapy.
- Awareness of these side effects can prevent serious dermatological complications.
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