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Updated: Sep 12, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Chitosan-derived materials as heterogeneous catalysts in A3-coupling and click reaction: A comprehensive review
Manpreet Kaur1, Divya1, Divya Bharti1
1Laboratory of Organic Synthesis and Catalysis, Department of Chemistry, Central University of Punjab, Bathinda 151401, India.
Abstract:
Chitosan, a natural biopolymer, has garnered huge attention as a support for the immobilization of different catalysts due to its ability to coordinate with various metals. Furthermore, the possibility of functionalization of OH and NH2 functional groups in chitosan makes it an attractive material for fine-tuning its properties for desired organic transformation. In this review article, we have covered the potential of chitosan/functionalized chitosan-based materials, including magnetic chitosan nanocomposites as recyclable heterogeneous catalysts in A3-coupling, and Huisgen 1,3-dipolar cycloaddition (click reaction). These metal-catalyzed transformations enable the synthesis of pharmaceutically important propargylamines and 1,2,3-triazoles in an atom-economical fashion. Chitosan (native or modified) plays a crucial role by stabilizing metal ions or nanoparticles, preventing their aggregation, minimizing metal leaching and enhancing catalyst reusability. Various aspects such as optimization conditions, recovery and reusability besides the synthesis of catalysts are highlighted.
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