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Updated: Sep 12, 2025
Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
Optical fogging is an effective method of reducing overestimation of myopia
Jiajia Lin1, Ting Chen2, Zequn Lin3
1Xiamen Eye Center and Eye Institute of Xiamen University, School of Medicine, Xiamen 361000, Fujian Province, China; Xiamen Clinical Research Center for Eye Diseases, Xiamen 361000, Fujian Province, China.
Background:
This study aimed to investigate the effectiveness of optical fogging in controlling accommodation and to evaluate its efficiency in reducing myopic overestimation among young adults, with the goal of providing scientific evidence for clinical refractive measurement.
Methods:
A total of 142 young adults aged 17 to 23 years (284 eyes) were enrolled. Refractive status and ocular biometric parameters were measured using open-field autorefractor and partial coherence interferometry under three conditions: baseline, optical fogging, and cycloplegia. Optical fogging was induced by wearing +2.00 D spherical lenses for 20 min, while cycloplegia was induced using 0.5 % compound tropicamide-phenylephrine eye drops. Eyes were categorized into overestimated and non-overestimated myopia groups based on whether the difference in spherical equivalent (SE) between cycloplegic and baseline measurements was ≥0.50 D. Changes in SE and lens thickness under the three conditions were analyzed, and the efficiency of optical fogging-induced accommodative control was calculated.
Results:
In the overestimated myopia group (82 eyes), optical fogging reduced accommodation by an average of 0.28 ± 0.37 D compared to baseline (p < 0.001), accounting for 36.84 % of the effect of cycloplegia (0.76 ± 0.29 D). In the total sample eyes, optical fogging reduced accommodation by 0.07 ± 0.34 D (p < 0.001), which corresponded to 21.88 % of the cycloplegic effect (0.32 ± 0.37 D). Lens thickness showed no significant change after optical fogging (all p > 0.05).
Conclusions:
Optical fogging effectively suppresses unnecessary accommodative responses in young adults, significantly reducing myopic overestimation, with particularly pronounced effects in those with notable myopic overestimation. Although optical fogging is less effective than cycloplegia in relaxing accommodation, it offers advantages in terms of ease of use, non-invasiveness, and good tolerance, making it highly applicable in clinical refractive measurement.
