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TSPO, reactive oxygen species and oxidative stress in physiological and pathological situations: a complex

Didier Morin1, Jean-Jacques Lacapère2

  • 1INSERM U955-IMRB, Team Ghaleh, UPEC, Ecole Nationale Vétérinaire d'Alfort, Créteil, France.

Biochimie
|August 4, 2025
PubMed

Insights

The translocator protein (TSPO) interacts with various molecules and is involved in cellular processes. This review explores TSPO

Area of Science:

  • Mitochondrial biology
  • Neuroscience
  • Cellular biochemistry

Background:

  • The translocator protein (TSPO), formerly peripheral benzodiazepine receptor (PBR), is located in the mitochondrial outer membrane.
  • TSPO's precise function remains unclear due to its interactions with ligands like cholesterol and porphyrins, and its involvement in diverse cellular processes.
  • Its presence across species and distribution in the central nervous system suggest a conserved, vital function.

Purpose of the Study:

  • To critically review the systems involving TSPO in reactive oxygen species (ROS) production.
  • To identify protein partners interacting with TSPO in ROS-related pathways.
  • To overview the relationship between TSPO, ROS, and disease.

Main Methods:

  • Literature review of studies on TSPO function.
  • Analysis of TSPO's role in ROS-generating systems (e.g., respiratory chain, NADPH oxidases).
  • Identification of interacting proteins and pathways.

Main Results:

  • TSPO is implicated in ROS production through various cellular systems.
  • Specific protein partners interacting with TSPO in these processes have been identified.
  • TSPO's link to inflammation-associated diseases and ROS production is highlighted.

Conclusions:

  • TSPO plays a significant role in cellular ROS production.
  • Understanding TSPO's interactions is crucial for comprehending its function in health and disease.
  • Further research into TSPO pathways could lead to novel therapeutic strategies for inflammatory diseases.
Keywords:
DiseasesMitochondriaOxidative stressReactive oxygen speciesTranslocator protein

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