Related Experiment Video
Updated: Sep 12, 2025
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
[A Case of Metastatic Renal Cell Carcinoma with LONG-Term Cancer Control by Repeated Dose Adjustment of IFNα]
Takeyuki Watanabe1, Hiroshi Okuno2, Naoki Hayata1
1The Department of Urology, National Hospital Organization Kyoto Medical Center.
Abstract:
A 64-year-old man was incidentally found to have a right renal tumor during a medical check-up. The tumor was diagnosed as renal cell carcinoma cT1aN0M0 by magnetic resonance imaging and computed tomography, and the left kidney was hypoplastic. Open partial nephrectomy was performed. Postoperatively, lung, stomach, and ipsilateral renal metastases were observed sequentially. By adjusting the dose of IFNα, the progression of cancer was controlled for 18 years while managing the side effects of IFNα. Despite the declining recommendation for IFNα in renal cancer practice guidelines, it may still be a viable treatment option in selected cases.
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