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Exploring the Causal Relationship Between Inflammatory Bowel Disease and Bell's Palsy Based on Inflammatory Proteins:
Daofeng Fan1, Wenbao Wu2, Jiaqian Dai1
1Department of Neurology, Longyan First Hospital Affiliated to Fujian Medical University, Longyan, Fujian, China.
Background:
The relationship between inflammatory bowel disease (IBD) and Bell's palsy remains unsubstantiated. This study aims to investigate the causal relationship between IBD and Bell's palsy.
Methods:
Using the two-sample Mendelian randomization (MR) method to explore the relationship between IBD and Bell's palsy. We applied Bell's palsy summary statistics from GWAS statistics for 91 inflammatory proteins and FinnGen R10 and IBD summary statistics from the International Inflammatory Bowel Disease Genetics Consortium.
Results:
The two-sample MR study indicates a significant positive association between IBD and Bell's palsy (OR: 1.13, 95% CI [1.03-1.23], p = 0.0065) and between Crohn's disease and Bell's palsy (OR: 1.10, 95% CI [1.02-1.18], p = 0.0088). After applying Bonferroni correction, IBD remained significantly correlated with Bell's palsy. Subsequently, the causal relationship between circulating inflammatory proteins in Bell's palsy and inflammatory bowel disease samples was reevaluated. The results of the MR study on inflammatory proteins in these two diseases suggest that the C-X-C Motif Chemokine Ligand 5 (CXCL5) is a potential protective factor and interleukin_17C (IL_17C) is a risk factor for these two diseases. Conversely, Signaling Lymphocytic Activation Molecule Family Member 1 (SLAMF1) is a protective factor for Bell's palsy and a risk factor for inflammatory bowel disease.
Conclusions:
The findings indicate that IBD may be a risk factor for Bell's palsy at the genetic level. CXCL5, IL_17C, and SLAMF1 are possible co-acting pathways between Bell's palsy and inflammatory bowel disease. These findings may provide new targets for the treatment of both diseases.
Insights
Inflammatory bowel disease (IBD) may genetically increase the risk of Bell's palsy. Specific inflammatory proteins like CXCL5, IL-17C, and SLAMF1 may link these conditions, offering potential therapeutic targets.
Area of Science:
- Genetics
- Immunology
- Gastroenterology
Background:
- The link between inflammatory bowel disease (IBD) and Bell's palsy is not well-established.
- This study investigates a potential causal relationship between IBD and Bell's palsy.
Purpose of the Study:
- To explore the genetic association between IBD and Bell's palsy.
- To identify shared inflammatory pathways implicated in both conditions.
Main Methods:
- Utilized two-sample Mendelian randomization (MR) analysis.
- Employed summary statistics from large-scale Genome-Wide Association Studies (GWAS) for Bell's palsy, IBD, and 91 inflammatory proteins.
Main Results:
- A significant genetic correlation was found between IBD and Bell's palsy (OR: 1.13).
- Crohn's disease also showed a significant association with Bell's palsy (OR: 1.10).
- CXCL5, IL-17C, and SLAMF1 were identified as potential shared inflammatory mediators.
Conclusions:
- Genetic evidence suggests IBD may be a risk factor for Bell's palsy.
- CXCL5, IL-17C, and SLAMF1 represent potential therapeutic targets for both IBD and Bell's palsy.
- Findings may inform novel treatment strategies for these distinct conditions.
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