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Programmed Aggregation of Lipidated Nitrobenzoselenadiazole as a Photo-Activatable Pyroptosis Inducer
Jong Min An1, Hyunyoung Choi2, Hyo In Kim3
1College of Medicine, Kyung Hee University, Seoul, 02447, Republic of Korea.
Advanced Healthcare Materials
|August 5, 2025
Summary
This study introduces novel nitrobenzoselenadiazole (NBSD) photosensitizers that enhance photodynamic therapy (PDT) through programmed aggregation. NBSD-NOc shows superior performance in tumor treatment and preventing recurrence.
Area of Science:
- Biochemistry
- Materials Science
- Oncology
Background:
- Photosensitizers are crucial for photodynamic therapy (PDT) against tumors.
- Photosensitizer aggregation in aqueous solutions reduces reactive oxygen species (ROS) generation and therapeutic efficacy.
Purpose of the Study:
- To develop a programmed aggregation system using nitrobenzoselenadiazole (NBSD) scaffolds with varying alkyl chain lengths.
- To investigate the potential of these NBSD derivatives as photo-activable pyroptosis inducers for cancer therapy.
Main Methods:
- Synthesis of NBSD scaffolds with C1, C3, and C8 alkyl chains.
- Evaluation of photophysical properties, cellular uptake, and ROS generation.
- Assessment of pyroptosis induction and biocompatibility in vitro and in vivo.
Main Results:
- NBSD derivatives demonstrated controlled aggregation and enhanced PDT effects.
- NBSD-NOc exhibited superior cellular uptake, pyroptosis induction, and biocompatibility.
- Programmed aggregation significantly improved photophysical properties and therapeutic outcomes.
Conclusions:
- Molecular design of NBSD scaffolds can control aggregation and optimize photophysical properties for enhanced PDT.
- NBSD-NOc presents a promising strategy for implantable photosensitizers in post-surgical tumor management.
- This approach offers a novel method to combat tumor recurrence by inducing programmed cell death.
