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Related Concept Videos

Allosteric Proteins-ATCase01:19

Allosteric Proteins-ATCase

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Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
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Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
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Related Experiment Video

Updated: Sep 12, 2025

Cell-Type Specific Protein Purification and Identification from Complex Tissues Using a Mutant Methionine tRNA Synthetase Mouse Line
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ALSUntangled #80: ISRIB (Integrated stress response InhiBitor).

Javier Mascias Cadavid1, Anna Mena Bravo1, Paul Barkhaus2

  • 1ALS Unit, Neurology Department, Hospital La Paz Institute for Health Research, Madrid, Spain.

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
|August 5, 2025
PubMed
Summary
This summary is machine-generated.

ISRIB may help amyotrophic lateral sclerosis (ALS) by reducing cellular stress, but more research is needed. Current evidence is insufficient to recommend ISRIB for ALS treatment due to a lack of clinical trials and verified benefits.

Keywords:
ISRISRIBstress granules

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Drug Discovery

Background:

  • Amyotrophic lateral sclerosis (ALS) involves an overactive integrated stress response (ISR).
  • The ISR contributes to stress granule formation, potentially triggering cell death in ALS.
  • ISRIB is a molecule investigated for its ability to attenuate the ISR.

Purpose of the Study:

  • To review the potential of ISRIB as an alternative treatment for ALS.
  • To assess the current evidence regarding ISRIB's efficacy and safety in ALS.

Main Methods:

  • Review of pre-clinical data in ALS cell models.
  • Analysis of anecdotal patient reports on symptomatic improvements.
  • Evaluation of existing literature on ISRIB's mechanism of action.

Main Results:

  • Pre-clinical studies suggest ISRIB is beneficial in ALS cell models.
  • Anecdotal reports indicate symptomatic improvements with minimal side effects in some patients.
  • Significant questions remain regarding ISRIB's solubility, bioavailability, and lack of clinical trials.

Conclusions:

  • ISRIB shows promise in pre-clinical ALS models by modulating the ISR.
  • Insufficient clinical evidence and safety data currently prevent endorsement of ISRIB for ALS treatment.
  • Further research, including clinical trials, is essential to determine ISRIB's safety and efficacy in ALS patients.