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Bench-Stable Imine Surrogates for the Synthesis of α-Carbonylenamines
Shun He1, Jizhou Feng2, Huan Yang3
1Precise Synthesis and Function Development Key Laboratory of Sichuan Province; College of Chemistry and Chemical Engineering, China West Normal University, no. 1 Shida Road, Nanchong 637002, P. R. China.
Abstract:
We report a versatile methodology for the synthesis of α-carbonylenamines using bench-stable imine surrogates via two distinct pathways. The protocol operates under mild conditions (room temperature), delivers high isolated yields (up to 99%), exhibits excellent selectivity (predominantly Z-configuration), and accommodates a broad substrate scope including functionalized amines and carbonyl compounds. This approach addresses limitations of traditional methods, such as instability of intermediates and harsh reaction conditions, and offers a practical route to enamine-based pharmaceuticals and heterocycles.
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