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Investigation of the association between MSR1 serum levels and type 2 diabetes: a preliminary study

Basak Ilgaz1, Gizem Akoglu1, Aleyna Alioglu1

  • 1Faculty of Medicine, Istanbul Aydın University, Istanbul, Türkiye.

Irish Journal of Medical Science
|August 5, 2025
PubMed
Abstract

Insights

Serum Macrophage Scavenger Receptor 1 (MSR1) levels showed a trend towards being higher in type 2 diabetes mellitus (T2DM) patients compared to controls. Further research is needed to confirm MSR1

Area of Science:

  • Biochemistry
  • Immunology
  • Endocrinology

Background:

  • Type 2 diabetes mellitus (T2DM) is a global metabolic disorder linked to insulin resistance and inflammation.
  • Macrophage Scavenger Receptor 1 (MSR1) is involved in immune responses and implicated in metabolic diseases.
  • The exact role of MSR1 in glucose metabolism and insulin sensitivity requires further elucidation.

Purpose of the Study:

  • To assess the association between serum MSR1 levels and insulin resistance in T2DM patients.
  • To explore MSR1 as a potential therapeutic target for T2DM.

Main Methods:

  • Cross-sectional study comparing 40 T2DM patients and 40 healthy controls.
  • Serum MSR1 levels quantified using a commercial ELISA kit.
  • Statistical analysis performed using IBM SPSS Statistics 21.

Main Results:

  • Serum MSR1 levels were numerically higher in the T2DM group than in the control group.
  • This difference did not reach statistical significance (p=0.897).

Conclusions:

  • A potential association between MSR1 and T2DM is suggested.
  • Larger studies are warranted to validate MSR1's role as a biomarker or therapeutic target in T2DM.
Keywords:
ELISAMSR1SerumT2DMType 2 Diabetes Mellitus

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