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Related Experiment Video

Updated: Sep 12, 2025

Development of an Algorithm to Perform a Comprehensive Study of Autonomic Dysreflexia in Animals with High Spinal Cord Injury Using a Telemetry Device
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Clinical Reasoning: A 72-Year-Old Man With Progressive Pan-Dysautonomia.

Aaron S Zelikovich1, Sabine Schneider1, Ayan S Mandal2

  • 1Department of Neurology, University of Pennsylvania, Philadelphia; and.

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|August 5, 2025
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Summary

Dysautonomia, or autonomic nervous system dysfunction, can be difficult to diagnose. This case study shows how autonomic and serologic testing aided in diagnosing autonomic failure, highlighting key diagnostic clues.

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Area of Science:

  • Neurology
  • Autonomic Neuroscience

Background:

  • Dysautonomia is a frequent clinical manifestation in various central and peripheral nervous system disorders.
  • Diagnosing dysautonomia presents challenges when a primary neurologic condition is not yet identified.

Purpose of the Study:

  • To illustrate the diagnostic process for autonomic failure in a patient with progressive dysautonomia.
  • To emphasize the importance of integrating clinical, laboratory, and imaging findings in diagnosing autonomic dysfunction.

Main Methods:

  • A case report of a 72-year-old male patient presenting with symptoms of dysautonomia.
  • Utilized a combination of autonomic function testing and serologic assays for diagnosis.

Main Results:

  • The patient exhibited progressive autonomic symptoms including orthostatic hypotension, urinary retention, erectile dysfunction, and constipation over nine months.
  • Diagnostic workup successfully identified the underlying cause of autonomic failure.

Conclusions:

  • This case underscores the differential diagnosis of autonomic failure.
  • Highlights the utility of specific clinical, laboratory, and imaging data in guiding diagnostic reasoning for dysautonomia.