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Preserving the first ray or first two rays in forefoot amputation for diabetic foot ulcers
Wei Mao1,2,3,4, Da-Jun Jiang5, Ying-Qi Zhang6,7
1Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. dr.mao.wei@gmail.com.
NPJ Digital Medicine
|August 6, 2025
Summary
Diabetic foot ulcer patients undergoing lower extremity amputation face high reulceration risks. Preserving the first ray reduces biomechanical stress and reulceration risk, while transmetatarsal amputation may be a better option if ray amputation is necessary.
Area of Science:
- Biomechanics
- Diabetic Foot Ulcers
- Surgical Outcomes
Background:
- Diabetic foot ulcers (DFUs) frequently lead to lower extremity amputation.
- Post-amputation reulceration and reamputation rates remain high, impacting patient quality of life.
Purpose of the Study:
- To investigate the biomechanical effects of different ray amputations (RAs).
- To assess the reulceration risk associated with various RAs in diabetic patients.
Main Methods:
- Development of finite-element models to simulate gait cycles.
- Simulation of different ray amputation scenarios (1 RA, 1-2 RA).
- Analysis of stress, strain, and plantar 'danger areas' for reulceration.
Main Results:
- Amputation of the first ray (1 RA) or first two rays (1-2 RA) significantly increased von Mises stress and strain.
- These RAs created larger plantar 'danger areas,' indicating a higher reulceration risk.
- Preserving the first ray or first two rays demonstrated a mitigating effect on reulceration risk.
Conclusions:
- Preserving the first ray or first two rays is crucial for maintaining foot biomechanics and reducing reulceration risk in DFU patients.
- If ray amputation is unavoidable, transmetatarsal amputation may be a more suitable surgical option to minimize reulceration risk.

