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Related Experiment Video

Updated: Sep 12, 2025

Quantitative Static and Dynamic Assessment of Balance Control in Stroke Patients

Quantitative Static and Dynamic Assessment of Balance Control in Stroke Patients

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Static and Dynamic Balance Is Impaired in Patients With Long-Term, Well-Controlled Acromegaly: A Cross-Sectional

Christian Rosendal¹, Annika Vestergaard Kvist², Rogério Pessoto Hirata³

¹Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark.

Clinical Endocrinology

|August 6, 2025

Summary

Balance is impaired in patients with long-term acromegaly, increasing fall risk. This study highlights the need for clinical attention to this complication and further research into therapeutic options.

Keywords:

acromegaly balance centre of pressure pituitary disease postural control

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Area of Science:

Endocrinology
Neurology
Gerontology

Background:

Acromegaly, a condition caused by excess growth hormone, can lead to various complications.
Balance impairment is an underrecognized but potentially serious consequence of acromegaly.

Purpose of the Study:

To assess and compare the balance capabilities of patients with long-term acromegaly to those of non-acromegalic controls.

Main Methods:

A cross-sectional study involving 17 patients with acromegaly and 17 matched controls.
Balance was assessed using a force platform (measuring Centre of Pressure area and velocity), the timed up-and-go (TUG) test, and questionnaires.
Neurological, visual, and musculoskeletal functions were also evaluated.

Main Results:

Patients with acromegaly exhibited significantly increased Centre of Pressure area, indicating poorer static balance, even after adjusting for neural and visual factors.
Dynamic balance was also impaired during cognitive tasks, and the TUG test results were significantly worse in the acromegaly group.
Impaired balance correlated with self-reported joint pain in acromegaly patients.

Conclusions:

Long-term acromegaly, even when controlled, is associated with significant impairments in both static and dynamic balance.
These findings underscore the importance of clinical evaluation for balance deficits in acromegaly patients.
Further research is necessary to develop effective therapeutic strategies for this overlooked complication.