Recent progress in stem cell and immune cell-based interventions for aging and age-related disorders

Area of Science:

• Gerontology and Regenerative Medicine
• Molecular Biology and Aging Research

Background:

• Human lifespan extension presents challenges in maintaining quality of life due to age-related decline and diseases.
• Deepening scientific understanding of aging mechanisms enables targeted interventions.

Purpose of the Study:

• To review current understanding of aging mechanisms and advancements in cell-based therapies for anti-aging.
• To explore the clinical translation of stem cell and immune cell technologies in age-related interventions.
• To identify challenges and future directions in cellular rejuvenation research for extending healthspan.

Main Methods:

• Systematic review of scientific literature on aging mechanisms.
• Analysis of recent advancements in stem cell and immune cell technologies.
• Examination of clinical applications of cell-based therapies in age-related interventions.

Main Results:

• Cell-based therapies offer significant anti-aging potential through metabolic reprogramming, cellular repair, tissue regeneration, senescent cell clearance, and immunomodulation.
• Cellular rejuvenation has emerged as a distinct research discipline.
• Metabolic modulation and molecular biology approaches are key to extending healthspan.

Conclusions:

• Cellular rejuvenation strategies, particularly cell-based therapies, hold substantial promise for extending human healthspan and improving geriatric care.
• Further research and clinical translation are needed to overcome challenges in the field.
• Targeted interventions in aging mechanisms are becoming increasingly feasible.