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Updated: Jun 18, 2026

Presynaptic Dopamine Dynamics in Striatal Brain Slices with Fast-scan Cyclic Voltammetry
Published on: January 12, 2012
Ventral Striatal Dopamine Increases following Hippocampal Sharp-Wave Ripples
Abstract:
Leading theories suggest that hippocampal replay drives offline learning through coupling with an internal teaching signal such as ventral striatal dopamine (DA); however, the relationship between hippocampal replay and dopamine is unknown. Simultaneous recording of putative hippocampal replay events (dorsal CA1 sharp-wave ripples, SWRs) and fiber photometry of ventral striatal DA in mice revealed a significant increase in DA following SWRs, peaking ∼0.3 s after SWRs. This result establishes for the first time a core theoretical requirement of offline learning in the mammalian brain.
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