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Updated: Sep 12, 2025

Techniques to Induce and Quantify Cellular Senescence
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Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

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Targeting CyclinD1-CDK6 to Mitigate Senescence-Driven Inflammation and Age-Associated Functional Decline

Adarsh Rajesh1, Aaron P Havas1, Rouven Arnold1

  • 1Sanford Burnham Prebys Medical Discovery Institute, Cancer Genome and Epigenetics Program, La Jolla, CA.

Biorxiv : the Preprint Server for Biology
|August 6, 2025
PubMed
Summary

Cyclin D1 (CCND1) and CDK6 drive inflammation in aging by promoting DNA damage in senescent cells. Inhibiting this pathway with Palbociclib reduces damage and frailty in aged mice, offering a new therapeutic target.

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