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Sex differences in pulmonary (arterial) hypertension: does it matter?

Corey E Ventetuolo1,2,3, Alexis E Sherman-Roe1

  • 1Department of Medicine, The Warren Alpert Medical School of Brown University.

Current Opinion in Pulmonary Medicine
|August 6, 2025
PubMed
Summary

Females have higher pulmonary arterial hypertension (PAH) prevalence but better survival and right ventricular (RV) function. This review explores the "sex paradox" in PAH, examining sex chromosomes, hormones, and immune function.

Keywords:
pulmonary arterial hypertensionright ventriclesex chromosomessex differences in pulmonary arterial hypertensionsex hormones

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