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Blinding

Blinding

Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.

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Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

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Fractional Carbon Dioxide Laser for Lichen Simplex Chronicus: A Randomized Controlled Trial.

Samia Esmat¹, Iman Sany¹, Lobna Alieldin¹

¹Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [Et Al.]

|August 6, 2025

Summary

Fractional carbon dioxide (CO2) laser effectively treats lichen simplex chronicus (LSC), with combined therapy showing superior results. This laser treatment offers a promising alternative for managing this chronic itchy skin condition.

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Area of Science:

Dermatology
Laser Therapy

Background:

Lichen simplex chronicus (LSC) is a prevalent itchy skin condition.
Topical corticosteroids are the standard first-line treatment.
Fractional CO2 laser shows promise for pruritus reduction in various dermatoses.

Purpose of the Study:

To compare the efficacy of fractional CO2 laser alone, topical corticosteroids alone, and combination therapy for LSC.
To evaluate treatment outcomes using patient and physician-reported measures.

Main Methods:

Sixty LSC patients were randomized into three groups: fractional CO2 laser, topical corticosteroid, or combination therapy.
Treatments were administered over three months.
Disease severity assessed via pruritus scales (VAS) and physician assessments (erythema, lichenification, scaling, excoriation, IGA).

Main Results:

Combination therapy achieved the highest rates of IGA score 0/1 (93.3%) and VAS 50% reduction (100%).
Fractional CO2 laser monotherapy showed significant improvement (66.7% VAS 50% reduction).
Topical corticosteroids alone demonstrated the lowest efficacy rates.

Conclusions:

Fractional CO2 laser is an effective treatment modality for LSC.
Combining fractional CO2 laser with topical corticosteroids enhances treatment outcomes for LSC.