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Fractional Carbon Dioxide Laser for Lichen Simplex Chronicus: A Randomized Controlled Trial
Samia Esmat1, Iman Sany1, Lobna Alieldin1
1Dermatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Summary
Fractional carbon dioxide (CO2) laser effectively treats lichen simplex chronicus (LSC), with combined therapy showing superior results. This laser treatment offers a promising alternative for managing this chronic itchy skin condition.
Area of Science:
- Dermatology
- Laser Therapy
Background:
- Lichen simplex chronicus (LSC) is a prevalent itchy skin condition.
- Topical corticosteroids are the standard first-line treatment.
- Fractional CO2 laser shows promise for pruritus reduction in various dermatoses.
Purpose of the Study:
- To compare the efficacy of fractional CO2 laser alone, topical corticosteroids alone, and combination therapy for LSC.
- To evaluate treatment outcomes using patient and physician-reported measures.
Main Methods:
- Sixty LSC patients were randomized into three groups: fractional CO2 laser, topical corticosteroid, or combination therapy.
- Treatments were administered over three months.
- Disease severity assessed via pruritus scales (VAS) and physician assessments (erythema, lichenification, scaling, excoriation, IGA).
Main Results:
- Combination therapy achieved the highest rates of IGA score 0/1 (93.3%) and VAS 50% reduction (100%).
- Fractional CO2 laser monotherapy showed significant improvement (66.7% VAS 50% reduction).
- Topical corticosteroids alone demonstrated the lowest efficacy rates.
Conclusions:
- Fractional CO2 laser is an effective treatment modality for LSC.
- Combining fractional CO2 laser with topical corticosteroids enhances treatment outcomes for LSC.
