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Unexpected effects of semaglutide on skeletal muscle mass and force-generating capacity in mice
Takuya Karasawa1, Ran Hee Choi2, Cesar A Meza2
1Diabetes & Metabolism Research Center, University of Utah, Salt Lake City, UT, USA; Department of Nutrition & Integrative Physiology, University of Utah, Salt Lake City, UT, USA; Research Institute for Sport Science, Nippon Sport Science University, Setagaya, Tokyo, Japan.
Cell Metabolism
|August 6, 2025
Abstract:
Loss of lean mass is a potential concern for semaglutide-induced weight loss. This study indicates that semaglutide has unexpected effects on skeletal muscle mass and strength in mice, demonstrating a need to more carefully assess these effects in humans.
