Related Experiment Video
Updated: Sep 12, 2025

Biochemical Titration of Glycogen In vitro
Published on: November 24, 2013
Glycogen shepherd guides the hidden trail of pentose phosphate pathway
Lin Wang1, Kaili Ma1, Lianjun Zhang1
1National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, Jiangsu 215123, China; Key Laboratory of Synthetic Biology Regulatory Element, Institute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Suzhou, Jiangsu 215123, China.
Abstract:
In a recent Molecular Cell study,1 Zhou et al. elucidated how glycogenolysis-derived glucose-1-phosphate mediates source-specific routing of glucose-6-phosphate into the pentose phosphate pathway through allosteric activation of glucose-6-phosphate dehydrogenase and liquid-liquid phase separation-mediated metabolic compartments. This compartmentalized distribution enables efficient reduced nicotinamide adenine dinucleotide phosphate (NADPH) generation from glycogenolytic flux, promoting Tm cell persistence by maintaining redox homeostasis.
Related Concept Videos
Other Glycolytic Pathways
Glycolysis: Preparatory Phase
Energy-requiring Steps of Glycolysis
Glycolysis
Biosynthesis of Polysaccharides
Glycolysis: Pay-off Phase
Step 1 - 5: Glycolysis Preparatory Phase
The first phase of glycolysis has 5 steps where the glucose is...

