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The Thyroid Gland01:23

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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Updated: Sep 12, 2025

A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images
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A Swin Transformer-Based Model for Thyroid Nodule Detection in Ultrasound Images

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Long-Term Surveillance for Benign Thyroid Nodules.

Manuela Macera1, Rossella Melcarne1, Giorgio Grani1

  • 1Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
|August 6, 2025
PubMed
Summary
This summary is machine-generated.

Regular ultrasound monitoring of benign thyroid nodules is recommended to detect changes. While size increase can occur, further research is needed for optimal surveillance protocols.

Keywords:
follow-upgrowthlong-termnatural historysurveillance

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Area of Science:

  • Endocrinology
  • Radiology
  • Oncology

Background:

  • High-resolution ultrasonography enhances thyroid nodule detection and risk stratification.
  • Standardized systems aim to reduce unnecessary biopsies and improve reporting consistency.
  • Most benign nodules require surveillance rather than immediate intervention.

Purpose of the Study:

  • To review literature on long-term follow-up of benign thyroid nodules.
  • To focus on ultrasound surveillance strategies and clinical practice guidelines.

Main Methods:

  • Narrative review of recent scientific literature.
  • Analysis of ultrasound surveillance strategies for benign thyroid nodules.

Main Results:

  • Benign thyroid nodule surveillance involves periodic ultrasound and clinical assessment.
  • Monitoring aims to detect growth, rule out false-negative classifications, and assess for compressive symptoms.
  • Evidence suggests benign nodules can increase in size, challenging traditional malignancy concerns.

Conclusions:

  • Current guidelines recommend regular monitoring for untreated benign thyroid nodules.
  • Follow-up intervals depend on various factors, including nodule risk and patient history.
  • Further research is required to optimize surveillance protocols for benign thyroid nodules.