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Is HA0-Mediated heat resistance in influenza a food safety concern? A methodological critique
Nader Ebrahimi1, Sanaz Sadeh1, Amir Ghaemi1
1Department of Influenza and other Respiratory Viruses, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran.
Virology
|August 6, 2025
Abstract:
We have read with interest the recent article by Zhirnov and Chernyshova, it addressed the stability of influenza A virus particles with uncleaved hemagglutinin (HA0) and its possible implication for food safety. While the article addresses an interesting topic, we would like to highlight several methodological and interpretative issues that, in our view, undermine the importance of the conclusions drawn.

